Pub. Date : 1996 Dec 12
PMID : 8982732
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Flupirtine increases the levels of glutathione and Bc1-2 in hNT (human Ntera/D1) neurons: mode of action of the drug-mediated anti-apoptotic effect. | flupirtine | charged multivesicular body protein 2A | Homo sapiens |
| 2 | During Glu/NMDA-mediated apoptosis the levels of the intracellular anti-apoptotic agents Bc1-2 and glutathione dropped by more than 50%. | Glutamic Acid | charged multivesicular body protein 2A | Homo sapiens |
| 3 | During Glu/NMDA-mediated apoptosis the levels of the intracellular anti-apoptotic agents Bc1-2 and glutathione dropped by more than 50%. | N-Methylaspartate | charged multivesicular body protein 2A | Homo sapiens |
| 4 | Flupirtine completely abolished this reduction of Bc1-2 and glutathione level at a concentration of 10 microM. | flupirtine | charged multivesicular body protein 2A | Homo sapiens |
| 5 | In the presence of 3 microM flupirtine a > 6-fold increase of the Bc1-2 (B-cell leukemia/lymphoma-2) level was observed in hNT neurons. | flupirtine a | charged multivesicular body protein 2A | Homo sapiens |
| 6 | We conclude that the Glu/NMDA-mediated neuronal cell death in vitro is controlled at least partially by Bc1-2 and glutathione. | Glutamic Acid | charged multivesicular body protein 2A | Homo sapiens |
| 7 | We conclude that the Glu/NMDA-mediated neuronal cell death in vitro is controlled at least partially by Bc1-2 and glutathione. | N-Methylaspartate | charged multivesicular body protein 2A | Homo sapiens |