| Protein Name | charged multivesicular body protein 2A |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 27243 |
| Gene Symbol | CHMP2A |
| UniProt | O43633 (CHM2A_HUMAN), A0A024R4S0 (A0A024R4S0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
53
Total Number of Articles : 45 |
Description |
charged multivesicular body protein 2A |
| Gene Summary |
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] |
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| Properties | |