Title : Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.

Pub. Date : 1996 Sep 15

PMID : 8823314






4 Functional Relationships(s)
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1 Cytochrome P450 2C11 was the main microsomal or plasma membrane protein that was alkylated by tienilic acid. Ticrynafen cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 Inhibitors of vesicular transport decreased flow cytometric recognition of both unalkylated and tienilic acid-alkylated cytochrome P450 2C11 on the plasma membrane of cultured hepatocytes. Ticrynafen cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
3 This recognition was decreased by adsorption with tienilic acid or by preexposure to the anti-tienilic acid or the anti-cytochrome P450 2C11 antibody. Ticrynafen cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
4 We conclude that cytochrome P450 2C11 is alkylated by tienilic acid and follows a vesicular route to the plasma membrane. Ticrynafen cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus