PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8823314-2 1996 Patients with tienilic acid hepatitis exhibit autoantibodies that recognize unalkylated cytochrome P450 2C9 in humans but recognize 2C11 in rats. Ticrynafen 14-27 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 88-107 8823314-6 1996 Cytochrome P450 2C11 was the main microsomal or plasma membrane protein that was alkylated by tienilic acid. Ticrynafen 94-107 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 0-20 8823314-7 1996 Inhibitors of vesicular transport decreased flow cytometric recognition of both unalkylated and tienilic acid-alkylated cytochrome P450 2C11 on the plasma membrane of cultured hepatocytes. Ticrynafen 96-109 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 120-140 8823314-9 1996 This recognition was decreased by adsorption with tienilic acid or by preexposure to the anti-tienilic acid or the anti-cytochrome P450 2C11 antibody. Ticrynafen 50-63 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 120-140 8823314-10 1996 We conclude that cytochrome P450 2C11 is alkylated by tienilic acid and follows a vesicular route to the plasma membrane. Ticrynafen 54-67 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 17-37