Title : Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N,N-diethylthiolcarbamate (DETC-ME). The terminal step in the bioactivation of disulfiram.

Pub. Date : 1995 Oct

PMID : 8654205






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6. detc-me cytochrome P450 family 2 subfamily C member 9 Homo sapiens