PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8654205-3	1995	DETC-Me sulfoxidation by microsomes from male and female rats treated with various cytochrome P450-enzyme inducers suggested that multiple enzymes can catalyze this reaction, and these include, CYP1A1/2, CYP2B1/2, and CYP3A1/2.	detc-me	0-7	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	194-200	
8654205-3	1995	DETC-Me sulfoxidation by microsomes from male and female rats treated with various cytochrome P450-enzyme inducers suggested that multiple enzymes can catalyze this reaction, and these include, CYP1A1/2, CYP2B1/2, and CYP3A1/2.	detc-me	0-7	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	204-210	
8654205-3	1995	DETC-Me sulfoxidation by microsomes from male and female rats treated with various cytochrome P450-enzyme inducers suggested that multiple enzymes can catalyze this reaction, and these include, CYP1A1/2, CYP2B1/2, and CYP3A1/2.	detc-me	0-7	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	218-224	
8654205-5	1995	The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6.	detc-me	30-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	117-123	
8654205-5	1995	The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6.	detc-me	30-37	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	129-135	
8654205-5	1995	The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6.	detc-me	30-37	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	138-144	
8654205-5	1995	The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6.	detc-me	30-37	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	150-156	
8654205-5	1995	The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6.	detc-me	30-37	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	162-168	
8654205-5	1995	The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6.	detc-me	30-37	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	171-177	
8654205-5	1995	The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6.	detc-me	30-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	183-189	
8654205-5	1995	The turnover rates (min-1) of DETC-Me sulfoxidation by the cDNA-expressed cytochrome P450 enzymes ranked as follows: CYP3A4 > CYP2A6 = CYP2C9 > CYP1A2 > CYP2B6 = CYP2E1 > CYP1A1 > CYP2D6.	detc-me	30-37	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	195-201	
8654205-7	1995	This complicated estimates of the contribution of CYP3A4 to DETC-Me sulfoxidation by human liver microsomes.	detc-me	60-67	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	50-56	
8654205-8	1995	The sample-to-sample variation in DETC-Me sulfoxidation by bank of human liver microsomes (N=13) correlated highly with coumarin 7-hydroxylation (r=0.88) and testosterone 6beta-hydroxylation (r=0.90), suggesting that CYP2A6 and CYP3A4/5 contribute to the sulfoxidation of DETC-Me by human liver microsomes.	detc-me	34-41	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	217-223	
8654205-8	1995	The sample-to-sample variation in DETC-Me sulfoxidation by bank of human liver microsomes (N=13) correlated highly with coumarin 7-hydroxylation (r=0.88) and testosterone 6beta-hydroxylation (r=0.90), suggesting that CYP2A6 and CYP3A4/5 contribute to the sulfoxidation of DETC-Me by human liver microsomes.	detc-me	34-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	228-234	
8654205-9	1995	Although, chlorzoxazone 6-hydroxylation (a marker for CYP2E1) correlated poorly with DETC-Me sulfoxidation, the correlation improved from r=0.07 to r=0.44 when DETC-Me sulfoxidation was studied in the presence of the CYP2A6 inhibitor, coumarin.	Chlorzoxazone	10-23	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	54-60	
8654205-9	1995	Although, chlorzoxazone 6-hydroxylation (a marker for CYP2E1) correlated poorly with DETC-Me sulfoxidation, the correlation improved from r=0.07 to r=0.44 when DETC-Me sulfoxidation was studied in the presence of the CYP2A6 inhibitor, coumarin.	detc-me	160-167	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	217-223	
8654205-11	1995	Polyclonal antibodies against CYP2E1 caused a modest inhibition (30%) of DETC-Me sulfoxidation by human liver microsomes.	detc-me	73-80	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	30-36	
8654205-12	1995	Anti-CYP3A1 antibodies completely inhibited DETC-Me sulfoxidation by cDNA-expressed CYP3A4.	detc-me	44-51	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	5-11	
8654205-12	1995	Anti-CYP3A1 antibodies completely inhibited DETC-Me sulfoxidation by cDNA-expressed CYP3A4.	detc-me	44-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-90	
8654205-13	1995	Under similar conditions, DETC-Me sulfoxidation by human liver microsomes was only partially inhibited by anti-CYP3A1 antibodies.	detc-me	26-33	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	111-117	
8654205-14	1995	Although studies with the rat and cDNA-expressed cytochrome P450 enzymes suggested that CYP1A2 contributed to DETC-Me sulfoxidation, this reaction was not inhibited by either furafylline ( a mechanism-based inhibitor of CYP1A2) or antibodies against CYP1A1/2.	detc-me	110-117	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	88-94	
8654205-17	1995	In human liver microsomes the CYP2A6, CYP2E1, and CYP3A4/5 all contribute significantly to the sulfoxidation of DETC-Me.	detc-me	112-119	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	30-36	
8654205-17	1995	In human liver microsomes the CYP2A6, CYP2E1, and CYP3A4/5 all contribute significantly to the sulfoxidation of DETC-Me.	detc-me	112-119	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	38-44	
8654205-17	1995	In human liver microsomes the CYP2A6, CYP2E1, and CYP3A4/5 all contribute significantly to the sulfoxidation of DETC-Me.	detc-me	112-119	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	50-56