Pub. Date : 1996 Feb
PMID : 8579112
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The intercellular distribution of O6-methylguanine-DNA methyltransferase (MGMT) mRNA expression has been investigated at the individual cell level in the liver of rats treated with dimethylnitrosamine using in situ hybridization. | Dimethylnitrosamine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 2 | The intercellular distribution of O6-methylguanine-DNA methyltransferase (MGMT) mRNA expression has been investigated at the individual cell level in the liver of rats treated with dimethylnitrosamine using in situ hybridization. | Dimethylnitrosamine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 3 | On the other hand, after exposure to dimethylnitrosamine, inducible MGMT mRNA was rapidly expressed in hepatocytes, especially in the centrilobular area at earlier time points, confirming our previous studies in which enzymatic activity has been measured in different purified cell populations obtained by differential centrifugation. | Dimethylnitrosamine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 4 | Immunohistochemical detection of the O6-methylguanine-DNA adduct formation was demonstrated in a dose-dependent fashion and was mainly found in the centrilobular hepatocytes where high levels of MGMT mRNA were present. | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |