PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8579112-1 1996 The intercellular distribution of O6-methylguanine-DNA methyltransferase (MGMT) mRNA expression has been investigated at the individual cell level in the liver of rats treated with dimethylnitrosamine using in situ hybridization. Dimethylnitrosamine 181-200 O-6-methylguanine-DNA methyltransferase Rattus norvegicus 34-72 8579112-1 1996 The intercellular distribution of O6-methylguanine-DNA methyltransferase (MGMT) mRNA expression has been investigated at the individual cell level in the liver of rats treated with dimethylnitrosamine using in situ hybridization. Dimethylnitrosamine 181-200 O-6-methylguanine-DNA methyltransferase Rattus norvegicus 74-78 8579112-4 1996 On the other hand, after exposure to dimethylnitrosamine, inducible MGMT mRNA was rapidly expressed in hepatocytes, especially in the centrilobular area at earlier time points, confirming our previous studies in which enzymatic activity has been measured in different purified cell populations obtained by differential centrifugation. Dimethylnitrosamine 37-56 O-6-methylguanine-DNA methyltransferase Rattus norvegicus 68-72 8579112-5 1996 Immunohistochemical detection of the O6-methylguanine-DNA adduct formation was demonstrated in a dose-dependent fashion and was mainly found in the centrilobular hepatocytes where high levels of MGMT mRNA were present. O-(6)-methylguanine 37-53 O-6-methylguanine-DNA methyltransferase Rattus norvegicus 195-199