Title : Angiotensin II binding sites in the rat fetus: characterization of receptor subtypes and interaction with guanyl nucleotides.

Pub. Date : 1993 Mar 19

PMID : 8469771






2 Functional Relationships(s)
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1 Autoradiography using 125I(-)[Sar1,Ile8]AII showed that 10 microM PD 123177 decreased binding to near-nonspecific levels in skin, skeletal muscle and adrenal medulla, whereas 10 microM DuP 753 blocked binding in the liver and lung. PD 123177 angiotensinogen Rattus norvegicus
2 However, dissociation occurred in the skin when AT2 sites were blocked with 10 microM PD 123177, and in liver, dissociation was not observed when AT1 sites were blocked with DuP 753. PD 123177 angiotensin II receptor, type 2 Rattus norvegicus