Pub. Date : 1993 Jul-Aug
PMID : 8397011
7 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Pyrroloquinoline quinone (PQQ) and its derivative, oxazo pyrroloquinoline (OPQ-G), protected rats from experimental liver injury induced by carbon tetrachloride (CCl4) in vivo. | PQQ Cofactor | C-C motif chemokine ligand 4 | Rattus norvegicus | ||
| 2 | Pyrroloquinoline quinone (PQQ) and its derivative, oxazo pyrroloquinoline (OPQ-G), protected rats from experimental liver injury induced by carbon tetrachloride (CCl4) in vivo. | PQQ Cofactor | C-C motif chemokine ligand 4 | Rattus norvegicus | ||
| 3 | This effect was observed after an intraperitoneal injection of 5 mg/kg PQQ or OPQ-G, which was given twice, 10 min and 1 h before CCl4 administration. | PQQ Cofactor | C-C motif chemokine ligand 4 | Rattus norvegicus | ||
| 4 | Pyrroloquinoline quinone protected primary cultured rat hepatocytes from CCl4 toxicity in vitro. | PQQ Cofactor | C-C motif chemokine ligand 4 | Rattus norvegicus | ||
| 5 | Pyrroloquinoline quinone derivatives (oxazo pyrroloquinoline, methyl-thioethyl oxazo pyrroloquinoline and PQQ-allylester) also protected the hepatocytes from CCl4 toxicity. | PQQ Cofactor | C-C motif chemokine ligand 4 | Rattus norvegicus | ||
| 6 | Pyrroloquinoline quinone and its derivatives inhibited the lucigenin-enhanced chemiluminescence from isolated hepatocytes initiated by CCl4. | PQQ Cofactor | C-C motif chemokine ligand 4 | Rattus norvegicus | ||
| 7 | These results suggest that eliminating free radicals is one of the protective mechanisms of PQQ and its derivatives against CCl4-induced liver injury. | PQQ Cofactor | C-C motif chemokine ligand 4 | Rattus norvegicus | ||