PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8397011-1 1993 Pyrroloquinoline quinone (PQQ) and its derivative, oxazo pyrroloquinoline (OPQ-G), protected rats from experimental liver injury induced by carbon tetrachloride (CCl4) in vivo. PQQ Cofactor 0-24 C-C motif chemokine ligand 4 Rattus norvegicus 162-166 8397011-1 1993 Pyrroloquinoline quinone (PQQ) and its derivative, oxazo pyrroloquinoline (OPQ-G), protected rats from experimental liver injury induced by carbon tetrachloride (CCl4) in vivo. PQQ Cofactor 26-29 C-C motif chemokine ligand 4 Rattus norvegicus 162-166 8397011-2 1993 This effect was observed after an intraperitoneal injection of 5 mg/kg PQQ or OPQ-G, which was given twice, 10 min and 1 h before CCl4 administration. PQQ Cofactor 71-74 C-C motif chemokine ligand 4 Rattus norvegicus 130-134 8397011-3 1993 Pyrroloquinoline quinone protected primary cultured rat hepatocytes from CCl4 toxicity in vitro. PQQ Cofactor 0-24 C-C motif chemokine ligand 4 Rattus norvegicus 73-77 8397011-5 1993 Pyrroloquinoline quinone derivatives (oxazo pyrroloquinoline, methyl-thioethyl oxazo pyrroloquinoline and PQQ-allylester) also protected the hepatocytes from CCl4 toxicity. PQQ Cofactor 0-24 C-C motif chemokine ligand 4 Rattus norvegicus 158-162 8397011-6 1993 Pyrroloquinoline quinone and its derivatives inhibited the lucigenin-enhanced chemiluminescence from isolated hepatocytes initiated by CCl4. PQQ Cofactor 0-24 C-C motif chemokine ligand 4 Rattus norvegicus 135-139 8397011-7 1993 These results suggest that eliminating free radicals is one of the protective mechanisms of PQQ and its derivatives against CCl4-induced liver injury. PQQ Cofactor 92-95 C-C motif chemokine ligand 4 Rattus norvegicus 124-128