Title : Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

Pub. Date : 1994 Jun

PMID : 8203907






1 Functional Relationships(s)
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1 Overall, these results establish that (a) TAO is a selective inhibitor of the human CYP3A subfamily; (b) ANF potently inhibits CYP2C8 and CYP2C9, in addition to CYPs 1A1 and 1A2; and (c) DDC cannot be employed as a diagnostic inhibitory probe for CYP2E1. Troleandomycin cytochrome P450 family 2 subfamily C member 9 Homo sapiens