PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8203907-0	1994	Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.	Troleandomycin	14-35	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	150-154	
8203907-0	1994	Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.	alpha-naphthoflavone	37-57	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	150-154	
8203907-0	1994	Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.	Ditiocarb	62-84	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	150-154	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	Troleandomycin	34-55	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	190-205	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	Troleandomycin	34-55	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	207-210	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	Troleandomycin	57-60	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	190-205	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	Troleandomycin	57-60	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	207-210	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	alpha-naphthoflavone	63-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	190-205	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	alpha-naphthoflavone	63-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	207-210	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	Ditiocarb	95-117	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	190-205	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	Ditiocarb	95-117	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	207-210	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	Ditiocarb	119-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	190-205	
8203907-1	1994	A variety of chemicals, including triacetyloleandomycin (TAO), alpha-naphthoflavone (ANF), and diethyldithiocarbamate (DDC), are widely used as inhibitory probes for select individual human cytochrome P450 (CYP) enzymes, despite the fact that the selectivity of these inhibitors has not been rigorously evaluated.	Ditiocarb	119-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	207-210	
8203907-6	1994	Although a previous study suggested that DDC is a selective inhibitor of CYP2E1, the present investigation shows that at concentrations required to inhibit CYP2E1 (IC50 approximately 125 microM when preincubated with NADPH), DDC also inhibited CYPs 1A1, 1A2, 2A6, 2B6, 2C8, 3A3, and 3A4.	Ditiocarb	41-44	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	73-79	
8203907-6	1994	Although a previous study suggested that DDC is a selective inhibitor of CYP2E1, the present investigation shows that at concentrations required to inhibit CYP2E1 (IC50 approximately 125 microM when preincubated with NADPH), DDC also inhibited CYPs 1A1, 1A2, 2A6, 2B6, 2C8, 3A3, and 3A4.	Ditiocarb	41-44	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	156-162	
8203907-6	1994	Although a previous study suggested that DDC is a selective inhibitor of CYP2E1, the present investigation shows that at concentrations required to inhibit CYP2E1 (IC50 approximately 125 microM when preincubated with NADPH), DDC also inhibited CYPs 1A1, 1A2, 2A6, 2B6, 2C8, 3A3, and 3A4.	NADP	217-222	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	156-162	
8203907-6	1994	Although a previous study suggested that DDC is a selective inhibitor of CYP2E1, the present investigation shows that at concentrations required to inhibit CYP2E1 (IC50 approximately 125 microM when preincubated with NADPH), DDC also inhibited CYPs 1A1, 1A2, 2A6, 2B6, 2C8, 3A3, and 3A4.	Ditiocarb	225-228	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	156-162	
8203907-7	1994	Decreasing the concentration of DDC to 10 microM, however, led to inhibition of CYP2A6 (65% inhibition) and CYP2B6 (50% inhibition), but none of the other P450s examined, including CYP2E1.	Ditiocarb	32-35	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	80-86	
8203907-7	1994	Decreasing the concentration of DDC to 10 microM, however, led to inhibition of CYP2A6 (65% inhibition) and CYP2B6 (50% inhibition), but none of the other P450s examined, including CYP2E1.	Ditiocarb	32-35	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	108-114	
8203907-7	1994	Decreasing the concentration of DDC to 10 microM, however, led to inhibition of CYP2A6 (65% inhibition) and CYP2B6 (50% inhibition), but none of the other P450s examined, including CYP2E1.	Ditiocarb	32-35	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	181-187	
8203907-8	1994	Overall, these results establish that (a) TAO is a selective inhibitor of the human CYP3A subfamily; (b) ANF potently inhibits CYP2C8 and CYP2C9, in addition to CYPs 1A1 and 1A2; and (c) DDC cannot be employed as a diagnostic inhibitory probe for CYP2E1.	Troleandomycin	42-45	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	138-144	
8203907-8	1994	Overall, these results establish that (a) TAO is a selective inhibitor of the human CYP3A subfamily; (b) ANF potently inhibits CYP2C8 and CYP2C9, in addition to CYPs 1A1 and 1A2; and (c) DDC cannot be employed as a diagnostic inhibitory probe for CYP2E1.	Troleandomycin	42-45	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	161-177	
8203907-8	1994	Overall, these results establish that (a) TAO is a selective inhibitor of the human CYP3A subfamily; (b) ANF potently inhibits CYP2C8 and CYP2C9, in addition to CYPs 1A1 and 1A2; and (c) DDC cannot be employed as a diagnostic inhibitory probe for CYP2E1.	Troleandomycin	42-45	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	247-253