Pub. Date : 1994 Sep
PMID : 8063421
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The level of anti-L. pneumophila antibodies in serum increased in both THC-treated and control mice; however, in the THC group IgG1 antibodies which are stimulated by Th2 cells were elevated while Th1-regulated, IgG2a antibodies were depressed. | Dronabinol | heart and neural crest derivatives expressed 2 | Mus musculus |
| 2 | Normal mouse splenocytes treated in vitro with THC and pokeweed mitogen showed suppressed production of gamma interferon, a cytokine associated with Th1 cells, but increased production of interleukin 4, a cytokine produced by Th2 cells. | Dronabinol | heart and neural crest derivatives expressed 2 | Mus musculus |
| 3 | These results suggest that THC decreases the development of anti-L. pneumophila immunity by causing a change in the balance of Th1 and Th2 activities. | Dronabinol | heart and neural crest derivatives expressed 2 | Mus musculus |