PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8063421-0 1994 Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Dronabinol 80-108 negative elongation factor complex member C/D, Th1l Mus musculus 49-52 8063421-3 1994 In this report, delta 9-tetrahydrocannabinol (THC), the major psychoactive cannabinoid of marijuana and an immunomodulator, suppressed development of secondary immunity to L. pneumophila, which correlated with a reduction in Th1 activity. Dronabinol 16-44 negative elongation factor complex member C/D, Th1l Mus musculus 225-228 8063421-3 1994 In this report, delta 9-tetrahydrocannabinol (THC), the major psychoactive cannabinoid of marijuana and an immunomodulator, suppressed development of secondary immunity to L. pneumophila, which correlated with a reduction in Th1 activity. Dronabinol 46-49 negative elongation factor complex member C/D, Th1l Mus musculus 225-228 8063421-6 1994 The level of anti-L. pneumophila antibodies in serum increased in both THC-treated and control mice; however, in the THC group IgG1 antibodies which are stimulated by Th2 cells were elevated while Th1-regulated, IgG2a antibodies were depressed. Dronabinol 117-120 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 127-131 8063421-6 1994 The level of anti-L. pneumophila antibodies in serum increased in both THC-treated and control mice; however, in the THC group IgG1 antibodies which are stimulated by Th2 cells were elevated while Th1-regulated, IgG2a antibodies were depressed. Dronabinol 117-120 heart and neural crest derivatives expressed 2 Mus musculus 167-170 8063421-6 1994 The level of anti-L. pneumophila antibodies in serum increased in both THC-treated and control mice; however, in the THC group IgG1 antibodies which are stimulated by Th2 cells were elevated while Th1-regulated, IgG2a antibodies were depressed. Dronabinol 117-120 immunoglobulin heavy variable V1-9 Mus musculus 212-217 8063421-8 1994 Normal mouse splenocytes treated in vitro with THC and pokeweed mitogen showed suppressed production of gamma interferon, a cytokine associated with Th1 cells, but increased production of interleukin 4, a cytokine produced by Th2 cells. Dronabinol 47-50 negative elongation factor complex member C/D, Th1l Mus musculus 149-152 8063421-8 1994 Normal mouse splenocytes treated in vitro with THC and pokeweed mitogen showed suppressed production of gamma interferon, a cytokine associated with Th1 cells, but increased production of interleukin 4, a cytokine produced by Th2 cells. Dronabinol 47-50 heart and neural crest derivatives expressed 2 Mus musculus 226-229 8063421-9 1994 Splenocytes from THC-treated mice, stimulated in vitro with either pokeweed mitogen or anti-CD3 antibodies, also produced less gamma interferon, indicating less Th1 activity in these mice. Dronabinol 17-20 negative elongation factor complex member C/D, Th1l Mus musculus 161-164 8063421-10 1994 These results suggest that THC decreases the development of anti-L. pneumophila immunity by causing a change in the balance of Th1 and Th2 activities. Dronabinol 27-30 negative elongation factor complex member C/D, Th1l Mus musculus 127-130 8063421-10 1994 These results suggest that THC decreases the development of anti-L. pneumophila immunity by causing a change in the balance of Th1 and Th2 activities. Dronabinol 27-30 heart and neural crest derivatives expressed 2 Mus musculus 135-138