Protein Name heart and neural crest derivatives expressed 2
Organism Mus musculus
Gene ID 15111
Gene Symbol

Hand2

UniProt Q61039 (HAND2_MOUSE)
Relationships Total Number of functionally related compound(s) : 908
Total Number of Articles : 1246
Description

heart and neural crest derivatives expressed 2

Gene Summary

Enables protein homodimerization activity and sequence-specific DNA binding activity. Contributes to E-box binding activity. Involved in several processes, including heart morphogenesis; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and nervous system development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hindlimb phalanx. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • heart- and neural crest derivatives-expressed protein 2
  • deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
  • heart and neural crest derivatives expressed transcript 2
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Properties