Pub. Date : 1995 Jan
PMID : 7798641
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Agonist-induced expression of tissue inhibitor of metalloproteinases and metalloproteinases by human macrophages is regulated by endogenous prostaglandin E2 synthesis. | Dinoprostone | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 2 | The regulatory effect of endogenously synthesized eicosanoid metabolites on the expression of tissue inhibitor of metalloproteinases (TIMP), interstitial collagenase, and 92-kDa gelatinase by human macrophages was examined. | Eicosanoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 3 | The regulatory effect of endogenously synthesized eicosanoid metabolites on the expression of tissue inhibitor of metalloproteinases (TIMP), interstitial collagenase, and 92-kDa gelatinase by human macrophages was examined. | Eicosanoids | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 4 | Regardless of the agonist used, TIMP production by macrophages was inhibited 65% by indomethacin, synthesis of interstitial collagenase was reduced 70%, and expression of 92-kDa gelatinase was decreased 40%. | Indomethacin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 5 | The agonist-stimulated increase in TIMP and collagenase production was directly correlated to the cumulative prostaglandin E2 level induced by the agonist used. | Dinoprostone | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 6 | The mechanism of indomethacin inhibition of TIMP and collagenase production was studied by labeling the cells with [35S]-methionine and performing immunoprecipitation using specific antiserum. | Indomethacin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 7 | Indomethacin markedly inhibited the lipopolysaccharide-induced biosynthesis of both TIMP and collagenase. | Indomethacin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 8 | Northern analysis revealed parallel suppression of TIMP and collagenase steady-state mRNA levels by indomethacin, indicating pretranslational control. | Indomethacin | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 9 | The regulation of inflammatory-cell TIMP and interstitial collagenase expression by prostaglandin E2 suggests that therapy inhibiting the cellular response to prostaglandins may be useful in cutaneous and systemic disease states involving macrophage-mediated connective-tissue destruction. | Dinoprostone | TIMP metallopeptidase inhibitor 1 | Homo sapiens |
| 10 | The regulation of inflammatory-cell TIMP and interstitial collagenase expression by prostaglandin E2 suggests that therapy inhibiting the cellular response to prostaglandins may be useful in cutaneous and systemic disease states involving macrophage-mediated connective-tissue destruction. | Prostaglandins | TIMP metallopeptidase inhibitor 1 | Homo sapiens |