PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7798641-0	1995	Agonist-induced expression of tissue inhibitor of metalloproteinases and metalloproteinases by human macrophages is regulated by endogenous prostaglandin E2 synthesis.	Dinoprostone	140-156	TIMP metallopeptidase inhibitor 1	Homo sapiens	30-68	
7798641-1	1995	The regulatory effect of endogenously synthesized eicosanoid metabolites on the expression of tissue inhibitor of metalloproteinases (TIMP), interstitial collagenase, and 92-kDa gelatinase by human macrophages was examined.	Eicosanoids	50-60	TIMP metallopeptidase inhibitor 1	Homo sapiens	94-132	
7798641-1	1995	The regulatory effect of endogenously synthesized eicosanoid metabolites on the expression of tissue inhibitor of metalloproteinases (TIMP), interstitial collagenase, and 92-kDa gelatinase by human macrophages was examined.	Eicosanoids	50-60	TIMP metallopeptidase inhibitor 1	Homo sapiens	134-138	
7798641-1	1995	The regulatory effect of endogenously synthesized eicosanoid metabolites on the expression of tissue inhibitor of metalloproteinases (TIMP), interstitial collagenase, and 92-kDa gelatinase by human macrophages was examined.	Eicosanoids	50-60	matrix metallopeptidase 1	Homo sapiens	141-188	
7798641-4	1995	Regardless of the agonist used, TIMP production by macrophages was inhibited 65% by indomethacin, synthesis of interstitial collagenase was reduced 70%, and expression of 92-kDa gelatinase was decreased 40%.	Indomethacin	84-96	TIMP metallopeptidase inhibitor 1	Homo sapiens	32-36	
7798641-6	1995	The agonist-stimulated increase in TIMP and collagenase production was directly correlated to the cumulative prostaglandin E2 level induced by the agonist used.	Dinoprostone	109-125	TIMP metallopeptidase inhibitor 1	Homo sapiens	35-39	
7798641-8	1995	The mechanism of indomethacin inhibition of TIMP and collagenase production was studied by labeling the cells with [35S]-methionine and performing immunoprecipitation using specific antiserum.	Indomethacin	17-29	TIMP metallopeptidase inhibitor 1	Homo sapiens	44-48	
7798641-9	1995	Indomethacin markedly inhibited the lipopolysaccharide-induced biosynthesis of both TIMP and collagenase.	Indomethacin	0-12	TIMP metallopeptidase inhibitor 1	Homo sapiens	84-88	
7798641-10	1995	Northern analysis revealed parallel suppression of TIMP and collagenase steady-state mRNA levels by indomethacin, indicating pretranslational control.	Indomethacin	100-112	TIMP metallopeptidase inhibitor 1	Homo sapiens	51-55	
7798641-11	1995	The regulation of inflammatory-cell TIMP and interstitial collagenase expression by prostaglandin E2 suggests that therapy inhibiting the cellular response to prostaglandins may be useful in cutaneous and systemic disease states involving macrophage-mediated connective-tissue destruction.	Dinoprostone	84-100	TIMP metallopeptidase inhibitor 1	Homo sapiens	36-40	
7798641-11	1995	The regulation of inflammatory-cell TIMP and interstitial collagenase expression by prostaglandin E2 suggests that therapy inhibiting the cellular response to prostaglandins may be useful in cutaneous and systemic disease states involving macrophage-mediated connective-tissue destruction.	Dinoprostone	84-100	matrix metallopeptidase 1	Homo sapiens	45-69	
7798641-11	1995	The regulation of inflammatory-cell TIMP and interstitial collagenase expression by prostaglandin E2 suggests that therapy inhibiting the cellular response to prostaglandins may be useful in cutaneous and systemic disease states involving macrophage-mediated connective-tissue destruction.	Prostaglandins	159-173	TIMP metallopeptidase inhibitor 1	Homo sapiens	36-40	
7798641-11	1995	The regulation of inflammatory-cell TIMP and interstitial collagenase expression by prostaglandin E2 suggests that therapy inhibiting the cellular response to prostaglandins may be useful in cutaneous and systemic disease states involving macrophage-mediated connective-tissue destruction.	Prostaglandins	159-173	matrix metallopeptidase 1	Homo sapiens	45-69