Protein Name TIMP metallopeptidase inhibitor 1
Organism Homo sapiens
Gene ID 7076
Gene Symbol


Relationships Total Number of functionally related compound(s) : 734
Total Number of Articles : 1049

TIMP metallopeptidase inhibitor 1

Gene Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

  • metalloproteinase inhibitor 1
  • collagenase inhibitor
  • epididymis secretory sperm binding protein
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