Title : N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes.

Pub. Date : 1995 Mar

PMID : 7628308






3 Functional Relationships(s)
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Protein Name
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1 In a panel of human microsomes, SMX-HA formation correlated with tolbutamide hydroxylase activity (r = 0.75; p = 0.01); CYP2C9 content (r = 0.79; p < 0.01) and was inhibited 70% by 500 microM tolbutamide and 90% by 100 microM sulfaphenazole. sulfamethoxazole hydroxylamine cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 Recombinant CYP2C9 catalyzed the N-hydroxylation of SMX. Sulfamethoxazole cytochrome P450 family 2 subfamily C member 9 Homo sapiens
3 SMX-HA formation in human hepatic microsomes was therefore mediated predominantly by CYP2C9. Sulfamethoxazole cytochrome P450 family 2 subfamily C member 9 Homo sapiens