PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7628308-0	1995	N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes.	Sulfamethoxazole	20-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55	
7628308-5	1995	SMX N-hydroxylation in phenobarbital-treated rat hepatic microsomes was inhibited 70% by anti-CYP2C6 antisera.	smx n	0-5	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	94-100	
7628308-5	1995	SMX N-hydroxylation in phenobarbital-treated rat hepatic microsomes was inhibited 70% by anti-CYP2C6 antisera.	Phenobarbital	23-36	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	94-100	
7628308-6	1995	Thus, the N4-hydroxylation of SMX by rat hepatic microsomes was mediated by members of the CYP2C subfamily, probably CYP2C6.	Sulfamethoxazole	30-33	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	117-123	
7628308-7	1995	In a panel of human microsomes, SMX-HA formation correlated with tolbutamide hydroxylase activity (r = 0.75; p = 0.01); CYP2C9 content (r = 0.79; p < 0.01) and was inhibited 70% by 500 microM tolbutamide and 90% by 100 microM sulfaphenazole.	sulfamethoxazole hydroxylamine	32-38	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	120-126	
7628308-8	1995	Recombinant CYP2C9 catalyzed the N-hydroxylation of SMX.	Sulfamethoxazole	52-55	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	12-18	
7628308-9	1995	SMX-HA formation in human hepatic microsomes was therefore mediated predominantly by CYP2C9.	Sulfamethoxazole	0-3	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	85-91	
7628308-10	1995	CYP-mediated reduction of SMX-HA to SMX was markedly induced in dexamethasone and phenobarbital-treated rat hepatic microsomes, and was attributed to CYP3A and CYP2B forms.	Sulfamethoxazole	26-29	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-3	
7628308-10	1995	CYP-mediated reduction of SMX-HA to SMX was markedly induced in dexamethasone and phenobarbital-treated rat hepatic microsomes, and was attributed to CYP3A and CYP2B forms.	Sulfamethoxazole	26-29	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	150-155	
7628308-10	1995	CYP-mediated reduction of SMX-HA to SMX was markedly induced in dexamethasone and phenobarbital-treated rat hepatic microsomes, and was attributed to CYP3A and CYP2B forms.	Sulfamethoxazole	36-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-3	
7628308-10	1995	CYP-mediated reduction of SMX-HA to SMX was markedly induced in dexamethasone and phenobarbital-treated rat hepatic microsomes, and was attributed to CYP3A and CYP2B forms.	Sulfamethoxazole	36-39	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	150-155	
7628308-10	1995	CYP-mediated reduction of SMX-HA to SMX was markedly induced in dexamethasone and phenobarbital-treated rat hepatic microsomes, and was attributed to CYP3A and CYP2B forms.	Dexamethasone	64-77	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-3	
7628308-10	1995	CYP-mediated reduction of SMX-HA to SMX was markedly induced in dexamethasone and phenobarbital-treated rat hepatic microsomes, and was attributed to CYP3A and CYP2B forms.	Phenobarbital	82-95	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-3	
7628308-10	1995	CYP-mediated reduction of SMX-HA to SMX was markedly induced in dexamethasone and phenobarbital-treated rat hepatic microsomes, and was attributed to CYP3A and CYP2B forms.	Phenobarbital	82-95	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	150-155