Pub. Date : 1995 Nov 3
PMID : 7592869
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, a novel protein, FKBP12.6, was found to inhibit calcineurin at clinically relevant FK506 concentrations. | Tacrolimus | FKBP prolyl isomerase 1B | Homo sapiens |
| 2 | In transfected Jurkat cells, FKBP12.6 is equivalent to FKBP12 at mediating the inhibitory effects of FK506. | Tacrolimus | FKBP prolyl isomerase 1B | Homo sapiens |
| 3 | Our results suggest that FKBP12.6 has both a unique physiological role in excitation-contraction coupling in cardiac muscle and the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. | Tacrolimus | FKBP prolyl isomerase 1B | Homo sapiens |
| 4 | Our results suggest that FKBP12.6 has both a unique physiological role in excitation-contraction coupling in cardiac muscle and the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. | Sirolimus | FKBP prolyl isomerase 1B | Homo sapiens |