Protein Name FKBP prolyl isomerase 1B
Organism Homo sapiens
Gene ID 2281
Gene Symbol

FKBP1B

UniProt P68106 (FKB1B_HUMAN), F8W6G9 (F8W6G9_HUMAN)
Relationships Total Number of functionally related compound(s) : 64
Total Number of Articles : 61
Description

FKBP prolyl isomerase 1B

Gene Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

synonyms
  • peptidyl-prolyl cis-trans isomerase FKBP1B
  • 12.6 kDa FK506-binding protein
  • 12.6 kDa FKBP
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Properties