Pub. Date : 1995 Oct 20
PMID : 7559661
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes. | Ceramides | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 2 | Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes. | Ceramides | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 3 | We have examined the role of sphingomyelin hydrolysis to ceramide in the suppression of CYP2C11, a major constitutive form of cytochrome P450, by interleukin-1. | Ceramides | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 4 | Treatment of the cells with either N-acetyl-D-erythro-sphingosine (C2-ceramide) or bacterial sphingomyelinase suppressed the expression of CYP2C11 and induced the expression of the interleukin-1-responsive alpha 1-acid glycoprotein mRNA. | N-acetylsphingosine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 5 | Treatment of the cells with either N-acetyl-D-erythro-sphingosine (C2-ceramide) or bacterial sphingomyelinase suppressed the expression of CYP2C11 and induced the expression of the interleukin-1-responsive alpha 1-acid glycoprotein mRNA. | N-acetylsphingosine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 6 | N-Acetyl-D-erythro-sphinganine mimicked the effect of C2-ceramide on CYP2C11, but not on alpha 1-acid glycoprotein expression. | n-acetyl-d-erythro-sphinganine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 7 | N-Acetyl-D-erythro-sphinganine mimicked the effect of C2-ceramide on CYP2C11, but not on alpha 1-acid glycoprotein expression. | N-acetylsphingosine | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 8 | These results are consistent with a role for ceramide or a related sphingolipid in mediating the down-regulation of CYP2C11, the induction of alpha 1-acid glycoprotein, and perhaps other cellular effects of interleukin-1 in hepatocytes. | Ceramides | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 9 | These results are consistent with a role for ceramide or a related sphingolipid in mediating the down-regulation of CYP2C11, the induction of alpha 1-acid glycoprotein, and perhaps other cellular effects of interleukin-1 in hepatocytes. | Sphingolipids | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |