Pub. Date : 1995 Jan
PMID : 7541023
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast, calcium response induced by a putative syk activator, H2O2, exhibited only a moderate sensitivity to PAO, demonstrating that PAO did not cause general suppression of all the functions leading to Ca2+ mobilization. | Calcium | spleen associated tyrosine kinase | Homo sapiens |
| 2 | In contrast, calcium response induced by a putative syk activator, H2O2, exhibited only a moderate sensitivity to PAO, demonstrating that PAO did not cause general suppression of all the functions leading to Ca2+ mobilization. | Hydrogen Peroxide | spleen associated tyrosine kinase | Homo sapiens |
| 3 | In contrast, calcium response induced by a putative syk activator, H2O2, exhibited only a moderate sensitivity to PAO, demonstrating that PAO did not cause general suppression of all the functions leading to Ca2+ mobilization. | oxophenylarsine | spleen associated tyrosine kinase | Homo sapiens |
| 4 | In contrast, calcium response induced by a putative syk activator, H2O2, exhibited only a moderate sensitivity to PAO, demonstrating that PAO did not cause general suppression of all the functions leading to Ca2+ mobilization. | oxophenylarsine | spleen associated tyrosine kinase | Homo sapiens |
| 5 | Since BCR cross-linking did not generate non-responsiveness to H2O2 in the presence of PAO, and PAO-treated cells remained responsive to syk activation by H2O2, we suppose that PAO may inhibit BCR-mediated signal transduction events upstream of syk activation. | oxophenylarsine | spleen associated tyrosine kinase | Homo sapiens |
| 6 | Since BCR cross-linking did not generate non-responsiveness to H2O2 in the presence of PAO, and PAO-treated cells remained responsive to syk activation by H2O2, we suppose that PAO may inhibit BCR-mediated signal transduction events upstream of syk activation. | oxophenylarsine | spleen associated tyrosine kinase | Homo sapiens |
| 7 | Since BCR cross-linking did not generate non-responsiveness to H2O2 in the presence of PAO, and PAO-treated cells remained responsive to syk activation by H2O2, we suppose that PAO may inhibit BCR-mediated signal transduction events upstream of syk activation. | Hydrogen Peroxide | spleen associated tyrosine kinase | Homo sapiens |
| 8 | Since BCR cross-linking did not generate non-responsiveness to H2O2 in the presence of PAO, and PAO-treated cells remained responsive to syk activation by H2O2, we suppose that PAO may inhibit BCR-mediated signal transduction events upstream of syk activation. | oxophenylarsine | spleen associated tyrosine kinase | Homo sapiens |
| 9 | Since BCR cross-linking did not generate non-responsiveness to H2O2 in the presence of PAO, and PAO-treated cells remained responsive to syk activation by H2O2, we suppose that PAO may inhibit BCR-mediated signal transduction events upstream of syk activation. | oxophenylarsine | spleen associated tyrosine kinase | Homo sapiens |
| 10 | PAO induced rapid and dose-dependent tyrosine phosphorylation of lyn and selectively inhibited BCR-mediated tyrosine phosphorylation of syk. | oxophenylarsine | spleen associated tyrosine kinase | Homo sapiens |
| 11 | PAO induced rapid and dose-dependent tyrosine phosphorylation of lyn and selectively inhibited BCR-mediated tyrosine phosphorylation of syk. | Tyrosine | spleen associated tyrosine kinase | Homo sapiens |
| 12 | The results presented in this paper demonstrate that PAO may provoke cellular desensitization process by alteration of the signal transducer functions of lyn and syk tyrosine kinase enzymes. | oxophenylarsine | spleen associated tyrosine kinase | Homo sapiens |