Title : Regulation of inducible nitric oxide synthase gene by interleukin-1 beta in rat vascular endothelial cells.

Pub. Date : 1994 Dec

PMID : 7528993






2 Functional Relationships(s)
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1 To elucidate the regulation of endothelial inducible nitric oxide synthase (iNOS), we studied the effects of interleukin (IL)-1 beta on production of nitric oxide (NO) and expression of iNOS mRNA and iNOS protein in cultured rat aortic endothelial cells (ECs) by measurement of NO2-/NO3- (NOx) and Northern blot and Western blot analyses. Nitric Oxide nitric oxide synthase 2 Rattus norvegicus
2 Transforming growth factor (TGF)-beta and dexamethasone blocked the IL-1 beta-induced NOx production as well as expression of iNOS mRNA and protein. Dexamethasone nitric oxide synthase 2 Rattus norvegicus