PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7528993-1 1994 To elucidate the regulation of endothelial inducible nitric oxide synthase (iNOS), we studied the effects of interleukin (IL)-1 beta on production of nitric oxide (NO) and expression of iNOS mRNA and iNOS protein in cultured rat aortic endothelial cells (ECs) by measurement of NO2-/NO3- (NOx) and Northern blot and Western blot analyses. Nitric Oxide 53-65 nitric oxide synthase 2 Rattus norvegicus 76-80 7528993-2 1994 Among several cytokines and bacterial lipopolysaccharide tested, IL-1 beta most effectively stimulated NOx production. nicotine 1-N-oxide 103-106 interleukin 1 beta Rattus norvegicus 65-74 7528993-3 1994 IL-1 beta dose and time dependently stimulated NOx production. nicotine 1-N-oxide 47-50 interleukin 1 beta Rattus norvegicus 0-9 7528993-4 1994 Northern blot analysis using cDNA for mouse liver iNOS as a probe showed that IL-1 beta induced expression of iNOS mRNA and stimulated NOx production in a dose- and time-dependent manner. nicotine 1-N-oxide 135-138 nitric oxide synthase 2, inducible Mus musculus 50-54 7528993-4 1994 Northern blot analysis using cDNA for mouse liver iNOS as a probe showed that IL-1 beta induced expression of iNOS mRNA and stimulated NOx production in a dose- and time-dependent manner. nicotine 1-N-oxide 135-138 interleukin 1 beta Mus musculus 78-87 7528993-5 1994 Transforming growth factor (TGF)-beta and dexamethasone blocked the IL-1 beta-induced NOx production as well as expression of iNOS mRNA and protein. Dexamethasone 42-55 interleukin 1 beta Rattus norvegicus 68-77 7528993-5 1994 Transforming growth factor (TGF)-beta and dexamethasone blocked the IL-1 beta-induced NOx production as well as expression of iNOS mRNA and protein. Dexamethasone 42-55 nitric oxide synthase 2 Rattus norvegicus 126-130 7528993-5 1994 Transforming growth factor (TGF)-beta and dexamethasone blocked the IL-1 beta-induced NOx production as well as expression of iNOS mRNA and protein. nicotine 1-N-oxide 86-89 interleukin 1 beta Rattus norvegicus 68-77 7528993-6 1994 TGF-beta dose dependently inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression. nicotine 1-N-oxide 58-61 transforming growth factor, beta 1 Rattus norvegicus 0-8 7528993-6 1994 TGF-beta dose dependently inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression. nicotine 1-N-oxide 58-61 interleukin 1 beta Rattus norvegicus 40-49