Title : Intratracheal instillation of silica up-regulates inducible nitric oxide synthase gene expression and increases nitric oxide production in alveolar macrophages and neutrophils.

Pub. Date : 1994 Oct

PMID : 7522485






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Intratracheal instillation of silica up-regulates inducible nitric oxide synthase gene expression and increases nitric oxide production in alveolar macrophages and neutrophils. Silicon Dioxide nitric oxide synthase 2 Rattus norvegicus
2 Northern blot analysis demonstrated that the steady-state levels of BALC iNOS mRNA were significantly increased by 3-fold following IT silica and by 7-fold following IT LPS. Silicon Dioxide nitric oxide synthase 2 Rattus norvegicus
3 Partially enriched fractions of either AM or leukocytes from silica-treated rats both exhibited significantly elevated iNOS mRNA in Northern analysis. Silicon Dioxide nitric oxide synthase 2 Rattus norvegicus
4 iNOS-dependent chemiluminescence was significantly increased in AM by 36-fold following IT silica and by 89-fold following IT LPS. Silicon Dioxide nitric oxide synthase 2 Rattus norvegicus