PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7522485-0 1994 Intratracheal instillation of silica up-regulates inducible nitric oxide synthase gene expression and increases nitric oxide production in alveolar macrophages and neutrophils. Silicon Dioxide 30-36 nitric oxide synthase 2 Rattus norvegicus 50-81 7522485-9 1994 Northern blot analysis demonstrated that the steady-state levels of BALC iNOS mRNA were significantly increased by 3-fold following IT silica and by 7-fold following IT LPS. Silicon Dioxide 135-141 nitric oxide synthase 2 Rattus norvegicus 73-77 7522485-10 1994 Partially enriched fractions of either AM or leukocytes from silica-treated rats both exhibited significantly elevated iNOS mRNA in Northern analysis. Silicon Dioxide 61-67 nitric oxide synthase 2 Rattus norvegicus 119-123 7522485-11 1994 iNOS-dependent chemiluminescence was significantly increased in AM by 36-fold following IT silica and by 89-fold following IT LPS. Silicon Dioxide 91-97 nitric oxide synthase 2 Rattus norvegicus 0-4