Pub. Date : 1994 Jul
PMID : 7519400
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). | Nitric Oxide | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D. | Dactinomycin | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. | Genistein | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. | herbimycin | nitric oxide synthase 2 | Rattus norvegicus |
| 5 | Herbimycin A and genistein also prevented IL-1 beta-induced iNOS mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells. | herbimycin | nitric oxide synthase 2 | Rattus norvegicus |
| 6 | Herbimycin A and genistein also prevented IL-1 beta-induced iNOS mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells. | Genistein | nitric oxide synthase 2 | Rattus norvegicus |