PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 134-146 interleukin 1 beta Rattus norvegicus 48-66 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 134-146 interleukin 1 beta Rattus norvegicus 68-77 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 165-172 interleukin 1 beta Rattus norvegicus 48-66 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 165-172 interleukin 1 beta Rattus norvegicus 68-77 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 214-226 interleukin 1 beta Rattus norvegicus 48-66 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 214-226 interleukin 1 beta Rattus norvegicus 68-77 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 214-226 nitric oxide synthase 2 Rattus norvegicus 108-112 7519400-4 1994 Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D. Nitrites 32-39 interleukin 1 beta Rattus norvegicus 61-70 7519400-4 1994 Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D. Dactinomycin 124-137 nitric oxide synthase 2 Rattus norvegicus 23-27 7519400-4 1994 Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D. Dactinomycin 124-137 interleukin 1 beta Rattus norvegicus 61-70 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. Genistein 31-40 interleukin 1 beta Rattus norvegicus 68-77 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. Genistein 31-40 nitric oxide synthase 2 Rattus norvegicus 119-123 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. herbimycin 45-57 interleukin 1 beta Rattus norvegicus 68-77 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. herbimycin 45-57 nitric oxide synthase 2 Rattus norvegicus 119-123 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. Nitrites 128-135 interleukin 1 beta Rattus norvegicus 68-77 7519400-7 1994 Herbimycin A and genistein also prevented IL-1 beta-induced iNOS mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells. herbimycin 0-12 interleukin 1 beta Rattus norvegicus 42-51 7519400-7 1994 Herbimycin A and genistein also prevented IL-1 beta-induced iNOS mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells. herbimycin 0-12 nitric oxide synthase 2 Rattus norvegicus 60-64 7519400-7 1994 Herbimycin A and genistein also prevented IL-1 beta-induced iNOS mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells. Genistein 17-26 interleukin 1 beta Rattus norvegicus 42-51 7519400-7 1994 Herbimycin A and genistein also prevented IL-1 beta-induced iNOS mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells. Genistein 17-26 nitric oxide synthase 2 Rattus norvegicus 60-64