Pub. Date : 1980 Apr
PMID : 7359015
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have found that the position on the PHA dose-response curve that is studied is the most important determinant of whether cortisol inhibits 3H-thymidine incorporation into lymphocyte DNA. | Tritium | lamin B receptor | Homo sapiens |
| 2 | We have found that the position on the PHA dose-response curve that is studied is the most important determinant of whether cortisol inhibits 3H-thymidine incorporation into lymphocyte DNA. | Thymidine | lamin B receptor | Homo sapiens |
| 3 | When monocytes were reduced from 14% to 1.4%, cortisol (5 microM) caused a 30% reduction in thymidine incorporation in cultures stimulated by 0.6 to 1.2 microgram/ml PHA. | Hydrocortisone | lamin B receptor | Homo sapiens |
| 4 | Much greater cortisol suppression of thymidine incorporation occurred if the concentration of PHA was reduced. | Thymidine | lamin B receptor | Homo sapiens |
| 5 | For example, reduction of the PHA concentration from 1.2 to 0.075 microgram/ml resulted in an increase in suppression by 5 microM cortisol from 5% to 90% even in the presence of 14% monocytes. | Hydrocortisone | lamin B receptor | Homo sapiens |
| 6 | These data indicate that the suppressive effects of glucocorticoids on blastogenesis and thymidine incorporation in vitro depend principally on the concentration of PHA used to stimulate blastogenesis and secondarily on the proportion of monocytes in the culture system. | Thymidine | lamin B receptor | Homo sapiens |