Pub. Date : 2022 May 15
PMID : 35532178
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The E2F1 induction was due to the elevation of its translation caused by ISO-induced miR-205 downregulation. | isorhapontigenin | microRNA 205 | Homo sapiens |
| 2 | Consistently, miR-205 was found to be overexpressed in human BCs, and ectopic expression of miR-205 mitigated ISO inhibitory effects against EGF-induced outcomes. | isorhapontigenin | microRNA 205 | Homo sapiens |
| 3 | Consistently, miR-205 was found to be overexpressed in human BCs, and ectopic expression of miR-205 mitigated ISO inhibitory effects against EGF-induced outcomes. | isorhapontigenin | microRNA 205 | Homo sapiens |
| 4 | Collectively, the results here demonstrate that ISO exhibits its preventive effect on EGF-induced human urothelial cell transformation by induction of p27 through a miR-205/E2F1 axis. | isorhapontigenin | microRNA 205 | Homo sapiens |