PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35532178-0	2022	Induction of p27 Contributes to Inhibitory Effect of Isorhapontigenin (ISO) on Malignant Transformation of Human Urothelial Cells.	isorhapontigenin	53-69	dynactin subunit 6	Homo sapiens	13-16	
35532178-0	2022	Induction of p27 Contributes to Inhibitory Effect of Isorhapontigenin (ISO) on Malignant Transformation of Human Urothelial Cells.	isorhapontigenin	71-74	dynactin subunit 6	Homo sapiens	13-16	
35532178-4	2022	The results showed here that ISO treatment inhibited EGF-induced cell transformation of human urothelial cells through induction of tumor suppressor p27 transcription secondary to activation of an E2F1-dependent pathway.	isorhapontigenin	29-32	epidermal growth factor	Homo sapiens	53-56	
35532178-4	2022	The results showed here that ISO treatment inhibited EGF-induced cell transformation of human urothelial cells through induction of tumor suppressor p27 transcription secondary to activation of an E2F1-dependent pathway.	isorhapontigenin	29-32	dynactin subunit 6	Homo sapiens	149-152	
35532178-4	2022	The results showed here that ISO treatment inhibited EGF-induced cell transformation of human urothelial cells through induction of tumor suppressor p27 transcription secondary to activation of an E2F1-dependent pathway.	isorhapontigenin	29-32	E2F transcription factor 1	Homo sapiens	197-201	
35532178-5	2022	ISO treatment rendered cells resistant to EGF-induced anchorage-independent growth concurrent with p27 protein induction in both UROtsa and SV-HUC-1 cells.	isorhapontigenin	0-3	epidermal growth factor	Homo sapiens	42-45	
35532178-5	2022	ISO treatment rendered cells resistant to EGF-induced anchorage-independent growth concurrent with p27 protein induction in both UROtsa and SV-HUC-1 cells.	isorhapontigenin	0-3	dynactin subunit 6	Homo sapiens	99-102	
35532178-6	2022	ISO inhibition of EGF-induced cell transformation could be completely reversed by knockdown of p27, indicating that this protein was essential for the noted ISO inhibitory action.	isorhapontigenin	0-3	epidermal growth factor	Homo sapiens	18-21	
35532178-6	2022	ISO inhibition of EGF-induced cell transformation could be completely reversed by knockdown of p27, indicating that this protein was essential for the noted ISO inhibitory action.	isorhapontigenin	0-3	dynactin subunit 6	Homo sapiens	95-98	
35532178-6	2022	ISO inhibition of EGF-induced cell transformation could be completely reversed by knockdown of p27, indicating that this protein was essential for the noted ISO inhibitory action.	isorhapontigenin	157-160	epidermal growth factor	Homo sapiens	18-21	
35532178-6	2022	ISO inhibition of EGF-induced cell transformation could be completely reversed by knockdown of p27, indicating that this protein was essential for the noted ISO inhibitory action.	isorhapontigenin	157-160	dynactin subunit 6	Homo sapiens	95-98	
35532178-7	2022	Mechanistic studies revealed that ISO treatment resulted in increased expression of E2F1, which in turn bound to its binding site in p27 promoter and initiated p27 transcription.	isorhapontigenin	34-37	E2F transcription factor 1	Homo sapiens	84-88	
35532178-7	2022	Mechanistic studies revealed that ISO treatment resulted in increased expression of E2F1, which in turn bound to its binding site in p27 promoter and initiated p27 transcription.	isorhapontigenin	34-37	dynactin subunit 6	Homo sapiens	133-136	
35532178-7	2022	Mechanistic studies revealed that ISO treatment resulted in increased expression of E2F1, which in turn bound to its binding site in p27 promoter and initiated p27 transcription.	isorhapontigenin	34-37	dynactin subunit 6	Homo sapiens	160-163	
35532178-8	2022	The E2F1 induction was due to the elevation of its translation caused by ISO-induced miR-205 downregulation.	isorhapontigenin	73-76	E2F transcription factor 1	Homo sapiens	4-8	
35532178-8	2022	The E2F1 induction was due to the elevation of its translation caused by ISO-induced miR-205 downregulation.	isorhapontigenin	73-76	microRNA 205	Homo sapiens	85-92	
35532178-9	2022	Consistently, miR-205 was found to be overexpressed in human BCs, and ectopic expression of miR-205 mitigated ISO inhibitory effects against EGF-induced outcomes.	isorhapontigenin	110-113	microRNA 205	Homo sapiens	14-21	
35532178-9	2022	Consistently, miR-205 was found to be overexpressed in human BCs, and ectopic expression of miR-205 mitigated ISO inhibitory effects against EGF-induced outcomes.	isorhapontigenin	110-113	microRNA 205	Homo sapiens	92-99	
35532178-9	2022	Consistently, miR-205 was found to be overexpressed in human BCs, and ectopic expression of miR-205 mitigated ISO inhibitory effects against EGF-induced outcomes.	isorhapontigenin	110-113	epidermal growth factor	Homo sapiens	141-144	
35532178-10	2022	Collectively, the results here demonstrate that ISO exhibits its preventive effect on EGF-induced human urothelial cell transformation by induction of p27 through a miR-205/E2F1 axis.	isorhapontigenin	48-51	epidermal growth factor	Homo sapiens	86-89	
35532178-10	2022	Collectively, the results here demonstrate that ISO exhibits its preventive effect on EGF-induced human urothelial cell transformation by induction of p27 through a miR-205/E2F1 axis.	isorhapontigenin	48-51	dynactin subunit 6	Homo sapiens	151-154	
35532178-10	2022	Collectively, the results here demonstrate that ISO exhibits its preventive effect on EGF-induced human urothelial cell transformation by induction of p27 through a miR-205/E2F1 axis.	isorhapontigenin	48-51	microRNA 205	Homo sapiens	165-172	
35532178-10	2022	Collectively, the results here demonstrate that ISO exhibits its preventive effect on EGF-induced human urothelial cell transformation by induction of p27 through a miR-205/E2F1 axis.	isorhapontigenin	48-51	E2F transcription factor 1	Homo sapiens	173-177