Title : Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target.

Pub. Date : 2022 Apr 19

PMID : 35438255






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Of particular importance, chronic ethanol feeding to C57BL/6 mice decreased the phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) at serine (S)1036/S1040 (S1029/S1033 human), sites linked with the inhibition of ASK1 death-promoting activity. Ethanol mitogen-activated protein kinase kinase kinase 5 Homo sapiens
2 Decreased phosphorylation at S1033 was also lower in liver of patients with severe AH compared to healthy controls, and phosphorylation at the ASK1 activation site (threonine (Thr)-838) was increased in patients with AH. Threonine mitogen-activated protein kinase kinase kinase 5 Homo sapiens
3 Decreased phosphorylation at S1033 was also lower in liver of patients with severe AH compared to healthy controls, and phosphorylation at the ASK1 activation site (threonine (Thr)-838) was increased in patients with AH. Threonine mitogen-activated protein kinase kinase kinase 5 Homo sapiens