Title : [Molecular pathogenesis and therapeutic targets in acute erythroid leukemia].

Pub. Date : 2022

PMID : 35264503






1 Functional Relationships(s)
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1 Along with the activated STAT5 pathway, a common feature across all AEL cases, these AEL cases exhibited enhanced cell proliferation and heme metabolism, and they showed high sensitivity to ruxolitinib in in vitro and in xenograft models, highlighting the potential role of JAK2 inhibition in AEL therapeutics. ruxolitinib signal transducer and activator of transcription 5A Homo sapiens