Pub. Date : 2022 Feb 20
PMID : 35205815
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results show that CUDC-907 significantly inhibits NB proliferation and colony growth, induces apoptosis, blocks cell cycle progression, inhibits MYCN, and enhances H3K9Ac levels by inhibiting the PI3K/AKT signaling pathway and HDAC function. | CUDC-907 | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | Our results show that CUDC-907 significantly inhibits NB proliferation and colony growth, induces apoptosis, blocks cell cycle progression, inhibits MYCN, and enhances H3K9Ac levels by inhibiting the PI3K/AKT signaling pathway and HDAC function. | CUDC-907 | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Overall, our findings highlight that the dual inhibition of PI3K and HDAC by CUDC-907 is an effective therapeutic strategy for NB and other MYC-dependent cancers. | CUDC-907 | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |