PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35205815-7 2022 Our results show that CUDC-907 significantly inhibits NB proliferation and colony growth, induces apoptosis, blocks cell cycle progression, inhibits MYCN, and enhances H3K9Ac levels by inhibiting the PI3K/AKT signaling pathway and HDAC function. CUDC-907 22-30 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 149-153 35205815-7 2022 Our results show that CUDC-907 significantly inhibits NB proliferation and colony growth, induces apoptosis, blocks cell cycle progression, inhibits MYCN, and enhances H3K9Ac levels by inhibiting the PI3K/AKT signaling pathway and HDAC function. CUDC-907 22-30 AKT serine/threonine kinase 1 Homo sapiens 205-208 35205815-9 2022 Overall, our findings highlight that the dual inhibition of PI3K and HDAC by CUDC-907 is an effective therapeutic strategy for NB and other MYC-dependent cancers. CUDC-907 77-85 MYC proto-oncogene, bHLH transcription factor Homo sapiens 140-143