Pub. Date : 2022 May 1
PMID : 35093482
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitigation of radiation-induced pneumonitis with the ACE-inhibitor lisinopril was evaluated in the 13.5 Gy rat PBI model. | Lisinopril | angiotensin I converting enzyme | Rattus norvegicus |
| 2 | Lisinopril abrogated radiation-induced increases in BALF MCP-1 (CCL2) and MIP-1alpha cytokine levels (p < 0.0001). | Lisinopril | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | Lisinopril abrogated radiation-induced increases in BALF MCP-1 (CCL2) and MIP-1alpha cytokine levels (p < 0.0001). | Lisinopril | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | Lisinopril abrogated radiation-induced increases in BALF MCP-1 (CCL2) and MIP-1alpha cytokine levels (p < 0.0001). | Lisinopril | C-C motif chemokine ligand 3 | Homo sapiens |
| 5 | Treatment with lisinopril reduced both ACE expression (p=0.006) and frequency of CD45+CD11b+ lung myeloid cells (p=0.004). | Lisinopril | angiotensin I converting enzyme | Homo sapiens |
| 6 | Treatment with lisinopril reduced both ACE expression (p=0.006) and frequency of CD45+CD11b+ lung myeloid cells (p=0.004). | Lisinopril | integrin subunit alpha M | Homo sapiens |
| 7 | In vitro, radiation injury acutely increased ACE activity (p=0.045) and reactive oxygen species (ROS) generation (p=0.004) in human monocytes, whereas treatment with lisinopril blocked radiation-induced increases in both ACE and ROS. | Lisinopril | angiotensin I converting enzyme | Homo sapiens |
| 8 | In vitro, radiation injury acutely increased ACE activity (p=0.045) and reactive oxygen species (ROS) generation (p=0.004) in human monocytes, whereas treatment with lisinopril blocked radiation-induced increases in both ACE and ROS. | Lisinopril | angiotensin I converting enzyme | Homo sapiens |