Protein Name integrin subunit alpha M
Organism Homo sapiens
Gene ID 3684
Gene Symbol


UniProt P11215 (ITAM_HUMAN)
Relationships Total Number of functionally related compound(s) : 1066
Total Number of Articles : 1629

integrin subunit alpha M

Gene Summary

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

  • integrin alpha-M
  • CD11 antigen-like family member B
  • CR-3 alpha chain
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