Title : PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3.

Pub. Date : 2021 Dec 2

PMID : 34857740






1 Functional Relationships(s)
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1 Following loss- and gain-of-function experiments, in vitro assays in high glucose-treated Schwann cells (SC4) and in vivo assays in db/db and ob/ob mice were performed to detect the effects of PIAS1 on autophagy and apoptosis of Schwann cells as well as symptoms of DPN by regulating the PPAR-gamma-miR-124-EZH2/STAT3. Glucose protein inhibitor of activated STAT 1 Mus musculus