Pub. Date : 2021 Apr 22
PMID : 33888130
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting "Undruggable" Myc-pathway genes. | omega-N-Allylarginine | bromodomain containing 4 | Homo sapiens |
| 2 | BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting "Undruggable" Myc-pathway genes. | omega-N-Allylarginine | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | BRD4, BRD3 and BRD2 proteins were detected by western blot in cells treated with ARV-825. | omega-N-Allylarginine | bromodomain containing 4 | Homo sapiens |
| 4 | BRD4, BRD3 and BRD2 proteins were detected by western blot in cells treated with ARV-825. | omega-N-Allylarginine | bromodomain containing 3 | Homo sapiens |
| 5 | BRD4, BRD3 and BRD2 proteins were detected by western blot in cells treated with ARV-825. | omega-N-Allylarginine | bromodomain containing 2 | Homo sapiens |
| 6 | In the T-ALL xenograft model, ARV-825 significantly reduced tumor growth and led to the dysregulation of Ki67 and cleaved caspase 3. | omega-N-Allylarginine | caspase 3 | Homo sapiens |