Pub. Date : 2021 Apr
PMID : 33652374
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Theophylline alleviates gentamicin-induced cytotoxicity to sensory hair cells by maintaining HDAC2 expression. | Theophylline | histone deacetylase 2 | Homo sapiens |
| 2 | Theophylline alleviates gentamicin-induced cytotoxicity to sensory hair cells by maintaining HDAC2 expression. | Gentamicins | histone deacetylase 2 | Homo sapiens |
| 3 | Our study aimed to examine the potential effects of theophylline, an HDAC2 agonist, on gentamicin-induced cytotoxicity to sensory hair cells. | Theophylline | histone deacetylase 2 | Homo sapiens |
| 4 | Our study aimed to examine the potential effects of theophylline, an HDAC2 agonist, on gentamicin-induced cytotoxicity to sensory hair cells. | Gentamicins | histone deacetylase 2 | Homo sapiens |
| 5 | HDAC2 expression was downregulated by gentamicin, which could be restored by theophylline. | Gentamicins | histone deacetylase 2 | Homo sapiens |
| 6 | HDAC2 expression was downregulated by gentamicin, which could be restored by theophylline. | Theophylline | histone deacetylase 2 | Homo sapiens |
| 7 | HDAC2 silencing in HEI-OC1 cells negated the beneficial effect of theophylline against gentamicin-induced growth defect and apoptosis activation. | Theophylline | histone deacetylase 2 | Homo sapiens |
| 8 | HDAC2 silencing in HEI-OC1 cells negated the beneficial effect of theophylline against gentamicin-induced growth defect and apoptosis activation. | Gentamicins | histone deacetylase 2 | Homo sapiens |
| 9 | Theophylline protects sensory hair cells from gentamicin ototoxicity by maintaining HDAC2 expression. | Theophylline | histone deacetylase 2 | Homo sapiens |
| 10 | Our study thereby discovers a critical role of HDAC2 in gentamicin-induced ototoxicity, which could shine light on potential therapeutic options for treatment against sensorineural hearing loss. | Gentamicins | histone deacetylase 2 | Homo sapiens |