Protein Name histone deacetylase 2
Organism Homo sapiens
Gene ID 3066
Gene Symbol


UniProt Q92769 (HDAC2_HUMAN)
Relationships Total Number of functionally related compound(s) : 287
Total Number of Articles : 349

histone deacetylase 2

Gene Summary

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

  • histone deacetylase 2
  • YY1-associated factor 1
  • protein deacylase HDAC2
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