Pub. Date : 2021 Apr 10
PMID : 33485947
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans. | gemcitabine | mucin 4, cell surface associated | Homo sapiens |
| 2 | MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans. | o-glycans | mucin 4, cell surface associated | Homo sapiens |
| 3 | We found that MUC4 knockout cells possess less tumorigenicity in vitro and in vivo, which was further reduced in PDAC cells that express aberrant overexpression of truncated O-glycans. | o-glycans | mucin 4, cell surface associated | Homo sapiens |
| 4 | Also, MUC4KO cells showed a further reduction of epidermal growth factor receptors (ErbB) and their downstream signaling pathways in truncated O-glycan expressing PDAC cells. | o-glycan | mucin 4, cell surface associated | Homo sapiens |
| 5 | MUC4 knockout differentially regulates apoptosis and cell cycle arrest in branched and truncated O-glycan expressing PDAC cells. | o-glycan | mucin 4, cell surface associated | Homo sapiens |
| 6 | Additionally, MUC4KO cells were found to be more sensitive to gemcitabine treatment. | gemcitabine | mucin 4, cell surface associated | Homo sapiens |
| 7 | Taken together, our results indicate that MUC4 enhances the malignant properties and gemcitabine resistance in PDAC tumors that aberrantly overexpress truncated O-glycans via altering ErbB/AKT signaling cascades and expression of nucleoside transporters, respectively. | gemcitabine | mucin 4, cell surface associated | Homo sapiens |
| 8 | Taken together, our results indicate that MUC4 enhances the malignant properties and gemcitabine resistance in PDAC tumors that aberrantly overexpress truncated O-glycans via altering ErbB/AKT signaling cascades and expression of nucleoside transporters, respectively. | o-glycans | mucin 4, cell surface associated | Homo sapiens |