Title : H2S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.

Pub. Date : 2021 Feb

PMID : 33389358






6 Functional Relationships(s)
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1 Herein, we reported that CPC inhibited autophagy and decreased the expression and activity of NF-E2-related factor 2 (Nrf2), then induced cell apoptosis. cytidylyl-(3'-5')-cytidine NFE2 like bZIP transcription factor 2 Homo sapiens
2 Herein, we reported that CPC inhibited autophagy and decreased the expression and activity of NF-E2-related factor 2 (Nrf2), then induced cell apoptosis. cytidylyl-(3'-5')-cytidine NFE2 like bZIP transcription factor 2 Homo sapiens
3 CPC inhibited autophagy and promoted apoptosis by inhibiting Nrf2 activation, which was H2S dependent. cytidylyl-(3'-5')-cytidine NFE2 like bZIP transcription factor 2 Homo sapiens
4 Furthermore, we found that CPC inhibited Nrf2 nucleus translocation by inhibiting glutathionylation of Kelch-like ECH-associated protein 1 (Keap1) at the Cys434 residue. cytidylyl-(3'-5')-cytidine NFE2 like bZIP transcription factor 2 Homo sapiens
5 Furthermore, we found that CPC inhibited Nrf2 nucleus translocation by inhibiting glutathionylation of Kelch-like ECH-associated protein 1 (Keap1) at the Cys434 residue. cytidylyl-(3'-5')-cytidine kelch like ECH associated protein 1 Homo sapiens
6 Furthermore, we found that CPC inhibited Nrf2 nucleus translocation by inhibiting glutathionylation of Kelch-like ECH-associated protein 1 (Keap1) at the Cys434 residue. cytidylyl-(3'-5')-cytidine kelch like ECH associated protein 1 Homo sapiens