| Protein Name | kelch like ECH associated protein 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9817 |
| Gene Symbol | KEAP1 |
| UniProt | Q14145 (KEAP1_HUMAN), A0A024R7C0 (A0A024R7C0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
659
Total Number of Articles : 912 |
Description |
kelch like ECH associated protein 1 |
| Gene Summary |
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
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