Title : Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPĪƒ in Parvalbumin Neurons.

Pub. Date : 2021 Feb 3

PMID : 33293360






2 Functional Relationships(s)
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1 The antidepressant drug fluoxetine, which is known to promote TRKB phosphorylation and reopen critical period-like plasticity in the adult brain, disrupts the interaction between TRKB and PTPsigma by binding to the transmembrane domain of TRKB. Fluoxetine protein tyrosine phosphatase, receptor type, S Mus musculus
2 Antidepressant fluoxetine disrupts the interaction between TRKB and PTPsigma, thereby increasing TRKB phosphorylation. Fluoxetine protein tyrosine phosphatase, receptor type, S Mus musculus