PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33293360-1	2021	Perineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulphate proteoglycans (CSPGs) which preferentially encase parvalbumin-containing (PV+) interneurons.	Chondroitin Sulfates	71-91	parvalbumin	Mus musculus	142-153	
33293360-3	2021	We found that reactivation of ocular dominance plasticity in the adult visual cortex induced by chondroitinase (chABC)-mediated PNN removal requires intact signaling by the neurotrophin receptor TRKB in PV+ neurons.	Penicillin G	128-131	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	96-110	
33293360-7	2021	The antidepressant drug fluoxetine, which is known to promote TRKB phosphorylation and reopen critical period-like plasticity in the adult brain, disrupts the interaction between TRKB and PTPsigma by binding to the transmembrane domain of TRKB.	Fluoxetine	24-34	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	62-66	
33293360-7	2021	The antidepressant drug fluoxetine, which is known to promote TRKB phosphorylation and reopen critical period-like plasticity in the adult brain, disrupts the interaction between TRKB and PTPsigma by binding to the transmembrane domain of TRKB.	Fluoxetine	24-34	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	179-183	
33293360-7	2021	The antidepressant drug fluoxetine, which is known to promote TRKB phosphorylation and reopen critical period-like plasticity in the adult brain, disrupts the interaction between TRKB and PTPsigma by binding to the transmembrane domain of TRKB.	Fluoxetine	24-34	protein tyrosine phosphatase, receptor type, S	Mus musculus	188-196	
33293360-7	2021	The antidepressant drug fluoxetine, which is known to promote TRKB phosphorylation and reopen critical period-like plasticity in the adult brain, disrupts the interaction between TRKB and PTPsigma by binding to the transmembrane domain of TRKB.	Fluoxetine	24-34	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	179-183	
33293360-8	2021	We propose that both chABC and fluoxetine reopen critical period-like plasticity in the adult visual cortex by promoting TRKB signaling in PV+ neurons through inhibition of TRKB dephosphorylation by the PTPsigma-CSPG complex.Significance statement:Critical period-like plasticity can be reactivated in the adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or by chronic antidepressant treatment.	chabc	21-26	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	121-125	
33293360-8	2021	We propose that both chABC and fluoxetine reopen critical period-like plasticity in the adult visual cortex by promoting TRKB signaling in PV+ neurons through inhibition of TRKB dephosphorylation by the PTPsigma-CSPG complex.Significance statement:Critical period-like plasticity can be reactivated in the adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or by chronic antidepressant treatment.	chabc	21-26	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	173-177	
33293360-8	2021	We propose that both chABC and fluoxetine reopen critical period-like plasticity in the adult visual cortex by promoting TRKB signaling in PV+ neurons through inhibition of TRKB dephosphorylation by the PTPsigma-CSPG complex.Significance statement:Critical period-like plasticity can be reactivated in the adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or by chronic antidepressant treatment.	chabc	21-26	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	376-390	
33293360-8	2021	We propose that both chABC and fluoxetine reopen critical period-like plasticity in the adult visual cortex by promoting TRKB signaling in PV+ neurons through inhibition of TRKB dephosphorylation by the PTPsigma-CSPG complex.Significance statement:Critical period-like plasticity can be reactivated in the adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or by chronic antidepressant treatment.	Fluoxetine	31-41	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	121-125	
33293360-8	2021	We propose that both chABC and fluoxetine reopen critical period-like plasticity in the adult visual cortex by promoting TRKB signaling in PV+ neurons through inhibition of TRKB dephosphorylation by the PTPsigma-CSPG complex.Significance statement:Critical period-like plasticity can be reactivated in the adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or by chronic antidepressant treatment.	Fluoxetine	31-41	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	173-177	
33293360-8	2021	We propose that both chABC and fluoxetine reopen critical period-like plasticity in the adult visual cortex by promoting TRKB signaling in PV+ neurons through inhibition of TRKB dephosphorylation by the PTPsigma-CSPG complex.Significance statement:Critical period-like plasticity can be reactivated in the adult visual cortex through disruption of perineuronal nets (PNNs) by chondroitinase treatment, or by chronic antidepressant treatment.	Fluoxetine	31-41	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	376-390	
33293360-9	2021	We now show that the effects of both chondroitinase and fluoxetine are mediated by the neurotrophin receptor TRKB in parvalbumin-containing (PV+) interneurons.	Fluoxetine	56-66	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	109-113	
33293360-9	2021	We now show that the effects of both chondroitinase and fluoxetine are mediated by the neurotrophin receptor TRKB in parvalbumin-containing (PV+) interneurons.	Fluoxetine	56-66	parvalbumin	Mus musculus	117-128	
33293360-12	2021	Antidepressant fluoxetine disrupts the interaction between TRKB and PTPsigma, thereby increasing TRKB phosphorylation.	Fluoxetine	15-25	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	59-63	
33293360-12	2021	Antidepressant fluoxetine disrupts the interaction between TRKB and PTPsigma, thereby increasing TRKB phosphorylation.	Fluoxetine	15-25	protein tyrosine phosphatase, receptor type, S	Mus musculus	68-76	
33293360-12	2021	Antidepressant fluoxetine disrupts the interaction between TRKB and PTPsigma, thereby increasing TRKB phosphorylation.	Fluoxetine	15-25	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	97-101