Title : Improved BMP2-CPC-stimulated osteogenesis in vitro and in vivo via modulation of macrophage polarization.

Pub. Date : 2021 Jan

PMID : 33255051






4 Functional Relationships(s)
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Protein Name
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1 In vitro, the alteration of macrophage polarization and cytokine secretion induced by BMP2-CPC or CPC was investigated. cytidylyl-(3'-5')-cytidine bone morphogenetic protein 2 Homo sapiens
2 The in vitro results indicated that BMP2-CPC and CPC induced different patterns of macrophage polarization and subsequently resulted in distinct patterns of cytokine expression and secretion. cytidylyl-(3'-5')-cytidine bone morphogenetic protein 2 Homo sapiens
3 Notably, BMP2-CPC induced more M2-phenotype polarization and higher expression of anti-inflammatory cytokines and growth factors than did CPC, which led to the better osteogenic effect of conditioned medium derived from BMP2-CPC-stimulated macrophages. cytidylyl-(3'-5')-cytidine bone morphogenetic protein 2 Homo sapiens
4 Notably, BMP2-CPC induced more M2-phenotype polarization and higher expression of anti-inflammatory cytokines and growth factors than did CPC, which led to the better osteogenic effect of conditioned medium derived from BMP2-CPC-stimulated macrophages. cytidylyl-(3'-5')-cytidine bone morphogenetic protein 2 Homo sapiens